HBV Mutation Detail Information

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Mutation Information

Mutation Site	C586A
Mutation Type	Nucleotide level
Gene/Protein/Region Type	S
Combined Mutation	s.V194A+s.Y206F
Nucleotide_Mutation	V194A
Country	Italy; United Kingdom and Germany

Literature Information

PubMed PMID	32312174
Disease	Chronic hepatitis B
Published Year	2020
Journal	Emerging microbes & infections
Title	Key mutations in the C-terminus of the HBV surface glycoprotein correlate with lower HBsAg levels in vivo, hinder HBsAg secretion in vitro and reduce HBsAg structural stability in the setting of HBeAg-negative chronic HBV genotype-D infection.
Author	Salpini R,Battisti A,Piermatteo L,Carioti L,Anastasiou OE,Gill US,Di Carlo D,Colagrossi L,Duca L,Bertoli A,La Rosa KY,Fabeni L,Iuvara A,Malagnino V,Cerva C,Lichtner M,Mastroianni CM,De Sanctis GM,Paoloni M,Marignani M,Pasquazzi C,Iapadre N,Parruti G,Vecchiet J,Sarmati L,Andreoni M,Angelico M,Grelli S,T Kennedy P,Verheyen J,Aquaro S,Silberstein FC,Perno CF,Svicher V
Evidence	Y206F showed multiple positive correlations with different HBsAg C-terminus mutations: V194A (phi = 0.23), M197T (phi = 0.32), S204T (phi = 0.26) and S210R (phi = 0.33) (Table 2).

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation