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Mutation Information
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Mutation Site
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C4A |
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Mutation Type
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Nucleotide level |
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Gene/Protein/Region Type
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RT |
Literature Information
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PubMed PMID
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17644816
|
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Published Year
|
2007 |
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Journal
|
Nucleic acids research |
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Title
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Active site binding and sequence requirements for inhibition of HIV-1 reverse transcriptase by the RT1 family of single-stranded DNA aptamers. |
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Author
|
Kissel JD,Held DM,Hardy RW,Burke DH |
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Evidence
|
The C4A and T11A/T12A mutations weakened the base-pairing potential of stem I, and caused a nearly 5-fold increase in the IC50 value relative to that of RT1t49 (IC50 = 17 +- 1.2 nM and 21 ± 3.3 nM, respectively.)
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HIV Mutation Detail Information