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Mutation Information
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Mutation Site
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C428W |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
|
L1 |
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Genotype/Subtype
|
HPV16 |
Literature Information
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PubMed PMID
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28968823
|
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Published Year
|
2017 |
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Journal
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The Journal of infectious diseases |
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Title
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Naturally Occurring Single Amino Acid Substitution in the L1 Major Capsid Protein of Human Papillomavirus Type 16: Alteration of Susceptibility to Antibody-Mediated Neutralization. |
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Author
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Ning T,Wolfe A,Nie J,Huang W,Chen XS,Wang Y |
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Evidence
|
Mean neutralization titers of most variants changed by approximately 4-fold, compared with the reference pseudovirions, with the C428W and K430Q mutations displaying 9-fold and 11-fold lower susceptibilities, respectively, to neutralization by the sera than the reference pseudovirions.
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HPV Mutation Detail Information