|
Mutation Information
|
Mutation Site
|
C428A |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
L1 |
|
Genotype/Subtype
|
HPV6;HPV11;HPV16;HPV18;HPV31;HPV26;HPV33;HPV35;HPV39;HPV45;HPV51;HPV52;HPV53;HPV56;HPV58;HPV59;HPV66;HPV68;HPV69;HPV70 |
|
Viral Reference
|
AAQ92369;
P17388;
NP_041787.1;
P24838;
P36741;
ACV88631.1;
AML80965;
NP_041848;
P36743;
AFS33402;
CAA54856;
ABO76893;
AGU90787;
AHV83654.1;
P50793;
AAC80442.1;
AMY16565;
AAA46935.1;
ANA05496;
P27232 |
Literature Information
|
PubMed PMID
|
32503989
|
|
Published Year
|
2020 |
|
Journal
|
Nature communications |
|
Title
|
Rational design of a multi-valent human papillomavirus vaccine by capsomere-hybrid co-assembly of virus-like particles. |
|
Author
|
Wang D,Liu X,Wei M,Qian C,Song S,Chen J,Wang Z,Xu Q,Yang Y,He M,Chi X,Huang S,Li T,Kong Z,Zheng Q,Yu H,Wang Y,Zhao Q,Zhang J,Xia N,Gu Y,Li S |
|
Evidence
|
We show that co-assembly between any pair of C175A and C428A mutants across at least nine HPV genotypes occurs at a preferred equal molar stoichiometry, irrespective of the type or number of L1 sequences.
|
|
|
HPV Mutation Detail Information