|
Mutation Information
|
Mutation Site
|
C380T |
|
Mutation Type
|
Nucleotide level |
|
Gene/Protein/Region Type
|
S |
|
Combined Mutation
|
s.C380T+s.C345A |
|
Nucleotide_Mutation
|
P127L |
|
Viral Reference
|
HM358335.1
|
|
Country
|
Iran |
Literature Information
|
PubMed PMID
|
27381922
|
|
Clinical information
|
Yes
|
|
Disease
|
HBV-HIV coinfection
|
|
Published Year
|
2017 |
|
Journal
|
Journal of medical virology |
|
Title
|
HBsAg mutations related to occult hepatitis B virus infection in HIV-positive patients result in a reduced secretion and conformational changes of HBsAg. |
|
Author
|
Sadeghi A,Shirvani-Dastgerdi E,Tacke F,Yagmur E,Poortahmasebi V,Poorebrahim M,Mohraz M,Hajabdolbaghi M,Rasoolinejad M,Abbasian L,Jafari R,Fakhari Z,Norouzi M,Ebrahimian A,Geravand B,Alavian SM,Jazayeri SM |
|
Evidence
|
Two groups of mutations became apparent. In one group, all cases with C345A had C380T; and in the other group, C379A was accompanied by C407A. Deduced amino acid translation revealed that these groups had sP127L and sP127T + sS136Y amino acid substitutions, respectively.
|
|
|
HBV Mutation Detail Information