HPV Mutation Detail Information

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Mutation Information
Mutation Site C335T
Mutation Type Nucleotide level
Gene/Protein/Region Type E6
Nucleotide_Mutation H78Y
Genotype/Subtype HPV16
Viral Reference K02718.1; NC_001526
Country Poland
Literature Information
PubMed PMID 27801430
Disease Cervical carcinoma; Low grade squamous intraepithelial lesion
Published Year 2017
Journal Acta biochimica Polonica
Title HPV16 E6 polymorphism and physical state of viral genome in relation to the risk of cervical cancer in women from the south of Poland.
Author Szostek S,Zawilinska B,Klimek M,Kosz-Vnenchak M
Evidence Sequence analysis of 80 studied samples showed substitutions in 9 nucleotides located between positions 122 and 350 (G122A, T137G, G145T, C153T, G176A, G188A, T295G, C335T, T350G) leading to the amino acid change (E7K, L12V,Q14H, T17I, D25N, E29K, D64E, H78Y, L83V) while other nucleotide substitutions (T109C, C256T, T286A, A289G) were silent.

Contents
Description
Mutation Information Note
  • Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)
Literature Information Note
  • Evidence: sentence contains this mutation information in the citation