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Mutation Information
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Mutation Site
|
C335T |
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Mutation Type
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Nucleotide level |
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Gene/Protein/Region Type
|
E6 |
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Nucleotide_Mutation
|
H78Y |
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Genotype/Subtype
|
HPV16 |
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Viral Reference
|
K02718.1
|
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Country
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Greek |
Literature Information
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PubMed PMID
|
23946477
|
|
Disease
|
Cervical carcinoma;
Cervical intraepithelial neoplasia
|
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Published Year
|
2013 |
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Journal
|
Journal of medical microbiology |
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Title
|
Molecular and evolutionary analysis of HPV16 E6 and E7 genes in Greek women. |
|
Author
|
Tsakogiannis D,Papadopoulou A,Kontostathi G,Ruether IGA,Kyriakopoulou Z,Dimitriou TG,Orfanoudakis G,Markoulatos P |
|
Evidence
|
Specific nucleotide changes within the E6 and E7 genes have been associated with the five major variant lineages: prototype strain (no changes), European variant E-G350 (T350G), E-C109G (T109C, T350G), E-G131G (A131G, T350G), East Asian (T178G, A647G), African type I (G132C, C143G, G145T, T286A, A289G, C335T, T789C, T795G), African type II (T109C, G132T, C143G, G145T, T286A, A289G, C335T, G403G, A647G, T789C, T795G) and Asian American (G145T, T286A, A289G, C335T, T350G, A532G, T732C, T789C, T795G) (Wu et al., 2006; Swan et al., 2005; Wheeler et al., 1997; Yamada et al., 1995, 1997).
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HPV Mutation Detail Information