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Mutation Information
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Mutation Site
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C280S |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
|
RT |
Literature Information
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PubMed PMID
|
33096918
|
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Published Year
|
2020 |
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Journal
|
Molecules (Basel, Switzerland) |
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Title
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Post-Catalytic Complexes with Emtricitabine or Stavudine and HIV-1 Reverse Transcriptase Reveal New Mechanistic Insights for Nucleotide Incorporation and Drug Resistance. |
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Author
|
Bertoletti N,Chan AH,Schinazi RF,Anderson KS |
|
Evidence
|
Recombinant RT protein (Q258C and C280S mutations), crosslinked to the dsDNA primer/template (21-mer/27-mer) with an N2-cystamine 2'-deoxyguanosine six bases upstream from the priming site (P site), was used for the structural studies.
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HIV Mutation Detail Information