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Mutation Information
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Mutation Site
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C2304A |
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Mutation Type
|
Nucleotide level |
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Gene/Protein/Region Type
|
C |
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Nucleotide_Mutation
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P135Q |
|
Country
|
China |
Literature Information
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PubMed PMID
|
24273041
|
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Disease
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HBV infection
|
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Published Year
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2014 |
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Journal
|
The Journal of infectious diseases |
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Title
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The impact of hepatitis B virus precore/core gene carboxyl terminal mutations on viral biosynthesis and the host immune response. |
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Author
|
Wu JF,Ni YH,Chen HL,Hsu HY,Chang MH |
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Evidence
|
The C2304A mutation results in a proline to glutamine substitution at amino acid 135 of HBcAg (P135Q; Figure 1), whereas the G1896A mutation results in a precore stop codon. In the survival analysis, the presence of C2304A (P135Q) and G1896A during the inflammatory phase predicted spontaneous HBeAg seroconversion (HR = 2.8 and 4.5; P = .01 and <.001, respectively; Table 3).
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HBV Mutation Detail Information