HIV Mutation Detail Information

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Mutation Information

Mutation Site	C22G
Mutation Type	Amino acid level
Gene/Protein/Region Type	Tat

Literature Information

PubMed PMID	33537927
Published Year	2021
Journal	Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology
Title	Mutations of Human DopamineTransporter at Tyrosine88, Aspartic Acid206, and Histidine547 Influence Basal and HIV-1 Tat-inhibited Dopamine Transport.
Author	Quizon PM,Yuan Y,Zhu Y,Zhou Y,Strauss MJ,Sun WL,Zhan CG,Zhu J
Evidence	Recombinant TatR1 − 86 inhibited dopamine uptake in wild-type hDAT, which was attenuated in either DAT mutants (D206L, D206L/H547A, and Y88F/D206L/H547A) or mutated TatR1 − 86 (K19A and C22G), demonstrating perturbed Tat-DAT interaction.

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation