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Mutation Information
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Mutation Site
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C22G |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
|
Tat |
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Immune Escape
|
Y |
Literature Information
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PubMed PMID
|
29666292
|
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Published Year
|
2018 |
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Journal
|
mBio |
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Title
|
Human Immunodeficiency Virus Tat Protein Aids V Region Somatic Hypermutation in Human B Cells. |
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Author
|
Wang X,Duan Z,Yu G,Fan M,Scharff MD |
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Evidence
|
Consistent with this notion, a single amino acid mutation at cysteine 22 of Tat (C22G) that abolishes its interaction with P-TEFb (6, 20) also eradicated the capacity of all of the forms of the Tat molecule to enhance SHM (Fig. 2b).
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HIV Mutation Detail Information