HBV Mutation Detail Information

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Mutation Information

Mutation Site	C1962D
Mutation Type	Nucleotide level
Gene/Protein/Region Type	C
Genotype/Subtype	B
Viral Reference	D00329
Country	Japan

Literature Information

PubMed PMID	22795596
Disease	Fulminant hepatitis B
Published Year	2012
Journal	Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology
Title	Association between S21 substitution in the core protein of hepatitis B virus and fulminant hepatitis.
Author	Inoue J,Ueno Y,Kawamura K,Yamamoto T,Mano Y,Miura M,Kobayashi T,Niitsuma H,Kondo Y,Kakazu E,Ninomiya M,Kimura O,Obara N,Kawagishi N,Kinouchi Y,Shimosegawa T
Evidence	RESULTS: In the analysis of full-genome sequences of HBV/B1 (FHB, n=11; non-FHB, n=35) including those from the databases, mutations at nt 1961 [T1961V (not T)] and nt 1962 [C1962D (not C)], which change S21 in the core protein, were found more frequently in FHB than in non-FHB (100% vs.

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Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation