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Mutation Information
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Mutation Site
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C189S |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
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BZLF1 |
Literature Information
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PubMed PMID
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29772230
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Published Year
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2018 |
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Journal
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Biochemical and biophysical research communications |
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Title
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Replacing C189 in the bZIP domain of Zta with S, T, V, or A changes DNA binding specificity to four types of double-stranded DNA. |
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Author
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Ray S,Tillo D,Assad N,Ufot A,Deppmann C,Durell SR,Porollo A,Vinson C |
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Evidence
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Zta(C189S) and Zta(C189T) bound the TRE (AP-1) motif (TGAG/CTCA) more strongly than wild-type Zta, while binding to other sequences, including the C/EBP half site GCAA was reduced.
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EBV Mutation Detail Information