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Mutation Information
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Mutation Site
|
C189S |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
BZLF1 |
Literature Information
|
PubMed PMID
|
18631132
|
|
Published Year
|
2008 |
|
Journal
|
Biochemical Society transactions |
|
Title
|
The reversal of epigenetic silencing of the EBV genome is regulated by viral bZIP protein. |
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Author
|
Karlsson QH,Schelcher C,Verrall E,Petosa C,Sinclair AJ |
|
Evidence
|
A single point mutant of Zta, C189S, is defective in binding to the methylated ZREs both in vitro and in vivo. This was used to probe the functional relevance of the interaction.
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EBV Mutation Detail Information