Mutation Information
Mutation Site
|
C189A |
Mutation Type
|
Amino acid level |
Gene/Protein/Region Type
|
BZLF1 |
Literature Information
PubMed PMID
|
16940523
|
Published Year
|
2006 |
Journal
|
Journal of virology |
Title
|
Amino acids in the basic domain of Epstein-Barr virus ZEBRA protein play distinct roles in DNA binding, activation of early lytic gene expression, and promotion of viral DNA replication. |
Author
|
Heston L,El-Guindy A,Countryman J,Dela Cruz C,Delecluse HJ,Miller G |
Evidence
|
The R183A, A185K, A185V, C189A, and R190A mutants were markedly impaired in DNA binding (<10% of that of the wild type).
|
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