|
Mutation Information
|
Mutation Site
|
C1858T |
|
Mutation Type
|
Nucleotide level |
|
Gene/Protein/Region Type
|
PreC |
|
Genotype/Subtype
|
A |
Literature Information
|
PubMed PMID
|
19263474
|
|
Published Year
|
2009 |
|
Journal
|
Hepatology (Baltimore, Md.) |
|
Title
|
The rtA194T polymerase mutation impacts viral replication and susceptibility to tenofovir in hepatitis B e antigen-positive and hepatitis B e antigen-negative hepatitis B virus strains. |
|
Author
|
Amini-Bavil-Olyaee S,Herbers U,Sheldon J,Luedde T,Trautwein C,Tacke F |
|
Evidence
|
To introduce the PC mutant (G1896A/C1858T) and the BCP double mutations (A1762T/G1764A) to the rtA194T vectors, the EcoRI‐NcoI fragment was cut out from each of the rtA194T vectors and ligated into the same region within the WT‐PC and WT‐BCP 1.28‐fold HBV replication‐competent plasmids, respectively
|
|
|
HBV Mutation Detail Information