|
Mutation Information
|
Mutation Site
|
C1858T |
|
Mutation Type
|
Nucleotide level |
|
Gene/Protein/Region Type
|
PreC |
|
Combined Mutation
|
prec.C1858T+prec.G1896A |
|
Genotype/Subtype
|
A |
Literature Information
|
PubMed PMID
|
15280461
|
|
Published Year
|
2004 |
|
Journal
|
Journal of virology |
|
Title
|
Basal core promoter and precore mutations in the hepatitis B virus genome enhance replication efficacy of Lamivudine-resistant mutants. |
|
Author
|
Tacke F,Gehrke C,Luedde T,Heim A,Manns MP,Trautwein C |
|
Evidence
|
The PC mutation (G1896A+C1858T) creates a translational stop codon resulting in absent HBeAg expression, whereas BCP mutations (A1762T/G1764A) reduce HBeAg expression by transcriptional mechanisms.
|
|
|
HBV Mutation Detail Information