HBV Mutation Detail Information

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Mutation Information

Mutation Site	C1858T
Mutation Type	Nucleotide level
Gene/Protein/Region Type	PreC

Literature Information

PubMed PMID	11778699
Disease	HBV associated liver disease
Published Year	2001
Journal	Virus genes
Title	Base-pair alterations in the epsilon-lower stem due to a novel double substitution in the precore gene of HBV-e negative variant were recovered by secondary mutations.
Author	Parvez MK,Thakur V,Kazim SN,Guptan RC,Hasnain SE,Sarin SK
Evidence	The destabilized C : G base-pairing in the lower stem of epsilon-hairpin due to G1896A substitution is reportedly compensated by a second C1858T mutation and suggested to play an important role in enhanced selection of the HBe negative variant.

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Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation