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Mutation Information
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Mutation Site
|
C1766T |
|
Mutation Type
|
Nucleotide level |
|
Gene/Protein/Region Type
|
BCP |
|
Genotype/Subtype
|
B;C |
|
Viral Reference
|
AY090460;
AY090457;
AY090454;
AF405706;
AB064310;
AF160501;
AF223965;
AB036910;
X69798;
AB032431;
X75657;
X85254;
M32138;
X65259;
AB014381;
M12906;
X04615;
AB033554;
AF100309;
D00329;
AF090842;
X51970;
X02763 |
|
Country
|
China |
Literature Information
|
PubMed PMID
|
20848146
|
|
Disease
|
Chronic hepatitis B;
Acute on chronic liver failure
|
|
Published Year
|
2011 |
|
Journal
|
Journal of gastroenterology |
|
Title
|
Association of hepatitis B virus mutations in basal core promoter and precore regions with severity of liver disease: an investigation of 793 Chinese patients with mild and severe chronic hepatitis B and acute-on-chronic liver failure. |
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Author
|
Xu Z,Ren X,Liu Y,Li X,Bai S,Zhong Y,Wang L,Mao P,Wang H,Xin S,Wong VW,Chan HL,Zoulim F,Xu D |
|
Evidence
|
Compared to CHB patients, ACLF patients had significantly higher mutation incidences at eight of the ten sites of interest, including T1753V (C/A/G), A1762T, G1764A, C1766T, and T1768A in the BCP region and G1862T, G1896A, and G1899A in the PC region.
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HBV Mutation Detail Information