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EBV Mutation Detail Information

> C174A Search Result


Mutation Information
Mutation Site C174A
Mutation Type Amino acid level
Gene/Protein/Region Type BILF1
Literature Information
PubMed PMID 30647152
Published Year 2019
Journal mBio
Title Distinct Roles of Extracellular Domains in the Epstein-Barr Virus-Encoded BILF1 Receptor for Signaling and Major Histocompatibility Complex Class I Downregulation.
Author Fares S,Spiess K,Olesen ETB,Zuo J,Jackson S,Kledal TN,Wills MR,Rosenkilde MM
Evidence To this end, both residues were mutated to alanine (C97A and C174A), and their surface expression and signaling were investigated. Both mutants showed reduced surface expression measured by surface ELISA against the N-terminally attached HA tag with expression of ∼30% (C97A) and 10% (C174A) of that of wild-type (wt) EBV-BILF1 (Fig. 2B).
Contents
Description
Mutation Information Note
  • Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)
Literature Information Note
  • Evidence: sentence contains this mutation information in the citation