HPV Mutation Detail Information

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Mutation Information

Mutation Site	C14A
Mutation Type	Amino acid level
Gene/Protein/Region Type	E2
Genotype/Subtype	HPV18
Viral Reference	NC_001357.1
Country	China

Literature Information

PubMed PMID	23451059
Disease	Cervical carcinoma
Published Year	2013
Journal	PloS one
Title	Sequence variation analysis of HPV-18 isolates in southwest China.
Author	Shen M,Ding X,Li T,Chen G,Zhou X
Evidence	DNA sequence analysis of the HPV-18 E2 region revealed seven variations: a T to G transversion at nt2856, G to C transversion at nt2857 and C to G transversion at nt2858, leading to a C14A AA substitution (n = 18, 32.1%); a G to T transversion at nt2859, leading to a V15L AA substitution (n = 18, 32.1%) (Fig. 1B); a C to G transversion at nt3084 and a G to C transversion at nt3085, leading to a R90A AA change (n = 11, 19.6%) (Fig. 1C); and a C to G transversion at nt3275, which does not lead to an AA change (n = 7, 12.5%) (Fig. 1D).

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Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation