HIV Mutation Detail Information

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Mutation Information

Mutation Site	C131Y
Mutation Type	Amino acid level
Gene/Protein/Region Type	Env

Literature Information

PubMed PMID	30566493
Published Year	2018
Journal	PloS one
Title	Guiding the humoral response against HIV-1 toward a MPER adjacent region by immunization with a VLP-formulated antibody-selected envelope variant.
Author	Beltran-Pavez C,Ferreira CB,Merino-Mansilla A,Fabra-Garcia A,Casadella M,Noguera-Julian M,Paredes R,Olvera A,Haro I,Brander C,Garcia F,Gatell JM,Yuste E,Sanchez-Merino V
Evidence	Mutation C131Y is especially relevant because this substitution eliminates the native disulfide bond between C131 and C157, thereby disrupting the architecture of the V1/V2 loop.

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation