HBV Mutation Detail Information

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Mutation Information
Mutation Site C121R
Mutation Type Amino acid level
Gene/Protein/Region Type S
Combined Mutation s.D144E+s.C121R+s.K122R
Country china
Literature Information
PubMed PMID 32763811
Disease Occult HBV infection
Published Year 2020
Journal Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology
Title The sK122R mutation of hepatitis B virus (HBV) is associated with occult HBV infection: Analysis of a large cohort of Chinese patients.
Author Wang J,Liu Y,Liao H,Liu L,Chen R,Si L,Luo D,Huang B,Li L,Jiang J,Xu D
Evidence The patient was treated with IFN-α+lamivudine, and sK122R-containing mutants persisted during the observation period. Specifically, sK122R, sK122R + D144E, sK122R + C121R + D144E, and sK122R + F134L + D144E mutants respectively comprised 86.4 %, 4.5 %, 4.5 %, and 4.5 % of tested viral clones at the first time-point (sample 1). ;Five viral strains from patient 1, wild-type (WT), sK122R (M1), sK122R + D144E (M2), sK122R + C121R + D144E (M3), and sK122R + F134L + D144E (M4), were transfected into HepG2 cells, and HBV DNA levels were determined in the culture supernatant after 72 h.

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Description
Mutation Information Note
  • Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)
Literature Information Note
  • Evidence: sentence contains this mutation information in the citation