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Mutation Information
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Mutation Site
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A92E |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
|
CA |
Literature Information
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PubMed PMID
|
32187548
|
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Published Year
|
2020 |
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Journal
|
Cell reports |
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Title
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Cyclophilin A Prevents HIV-1 Restriction in Lymphocytes by Blocking Human TRIM5α Binding to the Viral Core. |
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Author
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Selyutina A,Persaud M,Simons LM,Bulnes-Ramos A,Buffone C,Martinez-Lopez A,Scoca V,Di Nunzio F,Hiatt J,Marson A,Krogan NJ,Hultquist JF,Diaz-Griffero F |
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Evidence
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Infection of HIV-1-A92E/G94D viruses was not affected by disruption of CypA-capsid interactions, which correlates with the loss of TRIM5alphahu binding to HIV-1 cores bearing the A92E/G94D mutation.
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HIV Mutation Detail Information