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Mutation Information
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Mutation Site
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A77V |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
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CA |
Literature Information
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PubMed PMID
|
27307565
|
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Published Year
|
2016 |
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Journal
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Journal of virology |
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Title
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Capsid-CPSF6 Interaction Is Dispensable for HIV-1 Replication in Primary Cells but Is Selected during Virus Passage In Vivo. |
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Author
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Saito A,Henning MS,Serrao E,Dubose BN,Teng S,Huang J,Li X,Saito N,Roy SP,Siddiqui MA,Ahn J,Tsuji M,Hatziioannou T,Engelman AN,Yamashita M |
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Evidence
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To assess the requirement for optimal CPSF6-CA binding during infection of primary cells and in vivo, we utilized a novel CA mutation, A77V, that significantly reduced CA binding to CPSF6.
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HIV Mutation Detail Information