|
Mutation Information
|
Mutation Site
|
A71V |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
PR |
|
Combined Mutation
|
pr.I50V+pr.A71V |
|
Genotype/Subtype
|
B |
|
Viral Reference
|
NL4.3
|
|
Relevant Drug
|
darunavir (DRV) |
Literature Information
|
PubMed PMID
|
30543749
|
|
Published Year
|
2019 |
|
Journal
|
ACS infectious diseases |
|
Title
|
Structural Adaptation of Darunavir Analogues against Primary Mutations in HIV-1 Protease. |
|
Author
|
Lockbaum GJ,Leidner F,Rusere LN,Henes M,Kosovrasti K,Nachum GS,Nalivaika EA,Ali A,Yilmaz NK,Schiffer CA |
|
Evidence
|
A71V, a compensatory mutation that is far from the active site and almost always observed with I50V, restores the functionality to WT level (Km = 73 +- 9 muM), as previously reported.
|
|
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HIV Mutation Detail Information