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Mutation Information
|
Mutation Site
|
A647G |
|
Mutation Type
|
Nucleotide level |
|
Gene/Protein/Region Type
|
E7 |
|
Genotype/Subtype
|
HPV16 |
|
Country
|
Korea |
Literature Information
|
PubMed PMID
|
16012730
|
|
Disease
|
Cervical carcinoma
|
|
Published Year
|
2005 |
|
Journal
|
Oncology reports |
|
Title
|
Sequence variation and the transcriptional activity of the upstream regulatory region in human papillomavirus 16 E7 variants in cervical cancer of Korean women. |
|
Author
|
Kim YB,Song YS,Jeon YT,Park JS,Um SJ,Kim JW,Park NH,Kang SB,Lee HP |
|
Evidence
|
Using PCR-directed sequencing, the presence of sequence variations in URRs were analyzed and the sites of sequence variation were matched with the known transcriptional factor binding site (TFBS) in 26 HPV 16 E7 variants, 21 cases with A647G (KE7-1, high oncogenic potential) and 5 cases with T732C (KE7-2, low oncogenic potential).
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HPV Mutation Detail Information