|
Mutation Information
|
Mutation Site
|
A544C |
|
Mutation Type
|
Nucleotide level |
|
Gene/Protein/Region Type
|
P |
|
Nucleotide_Mutation
|
N474H |
|
Country
|
Argentina |
Literature Information
|
PubMed PMID
|
25244642
|
|
Disease
|
Chronic hepatitis B
|
|
Published Year
|
2014 |
|
Journal
|
Journal of viral hepatitis |
|
Title
|
Hepatitis B virus depicts a high degree of conservation during the immune-tolerant phase in familiarly transmitted chronic hepatitis B infection: deep-sequencing and phylogenetic analysis. |
|
Author
|
Sede M,Lopez-Ledesma M,Frider B,Pozzati M,Campos RH,Flichman D,Quarleri J |
|
Evidence
|
In comparison with the other 29 complete sequences of genotype D1, 13 distinctive specific point mutations were observed in the nine complete genomes from the family as follows (amino acid changes at Polymerase): A544C (N474H), T996C,A1361T (Y746F), A1634G, G2648A, T2859C (S185P),C2928T (R208C), A2991G (S229G), A3000C (I232L),G3039A (G245L),and 3171A (H289N). C3083A (S259R), G3120A (K272E),and 3171A (H289N).
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HBV Mutation Detail Information