HBV Mutation Detail Information

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Mutation Information

Mutation Site	A527T
Mutation Type	Amino acid level
Gene/Protein/Region Type	P
Genotype/Subtype	C
Country	Japan

Literature Information

PubMed PMID	16982790
Disease	Chronic hepatitis B
Published Year	2006
Journal	Antimicrobial agents and chemotherapy
Title	Emergence of a novel lamivudine-resistant hepatitis B virus variant with a substitution outside the YMDD motif.
Author	Yatsuji H,Noguchi C,Hiraga N,Mori N,Tsuge M,Imamura M,Takahashi S,Iwao E,Fujimoto Y,Ochi H,Abe H,Maekawa T,Tateno C,Yoshizato K,Suzuki F,Kumada H,Chayama K
Evidence	Comparison by the direct sequence method of nucleotide sequences obtained before and after the viral breakthrough showed three nucleotide substitutions that induced two amino acid substitutions in both spacer (polS331C) and reverse transcriptase (polA527T or rtA181T) domains of the polymerase (Fig. (Fig.1B1B and and2).2).

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Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation