|
Mutation Information
|
Mutation Site
|
A514C |
|
Mutation Type
|
Nucleotide level |
|
Gene/Protein/Region Type
|
S |
|
Combined Mutation
|
p.C512T+p.A514C |
|
Nucleotide_Mutation
|
P120S |
|
Country
|
Germany |
Literature Information
|
PubMed PMID
|
9425945
|
|
Disease
|
Fulminant hepatitis B;
Liver cirrhosis
|
|
Published Year
|
1998 |
|
Journal
|
Hepatology (Baltimore, Md.) |
|
Title
|
Hepatitis B virus with antigenically altered hepatitis B surface antigen is selected by high-dose hepatitis B immune globulin after liver transplantation. |
|
Author
|
Protzer-Knolle U,Naumann U,Bartenschlager R,Berg T,Hopf U,Meyer zum Büschenfelde KH,Neuhaus P,Gerken G |
|
Evidence
|
Inchronichepatitis B patients before OLT, point mutations at nt487,496, 499, 514, 523, 532, 568,and 574 were detected that do not alter the s-protein sequence but may affect HBV polymerase
|
|
|
HBV Mutation Detail Information