HIV Mutation Detail Information

> A508V Search Result

Mutation Information

Mutation Site	A508V
Mutation Type	Amino acid level
Gene/Protein/Region Type	RT

Literature Information

PubMed PMID	33715562
Published Year	2021
Journal	Journal of enzyme inhibition and medicinal chemistry
Title	Flavonoids and Acid-Hydrolysis derivatives of Neo-Clerodane diterpenes from Teucrium flavum subsp. glaucum as inhibitors of the HIV-1 reverse transcriptase-associated RNase H function.
Author	Fois B,Corona A,Tramontano E,Distinto S,Maccioni E,Meleddu R,Caboni P,Floris C,Cottiglia F
Evidence	The single point mutation of residue Ala508 to Val, in an attempt to reduce the space available for flavuglaucin B accommodation, seems to confirm this mechanism of action.

Contents
Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation