HIV Mutation Detail Information

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Mutation Information

Mutation Site	A502F
Mutation Type	Amino acid level
Gene/Protein/Region Type	RT
Relevant Drug	NNRTIs;efavirenz (EFV)

Literature Information

PubMed PMID	32183488
Published Year	2020
Journal	Molecules (Basel, Switzerland)
Title	2-(Arylamino)-6-(trifluoromethyl)nicotinic Acid Derivatives: New HIV-1 RT Dual Inhibitors Active on Viral Replication.
Author	Corona A,Onnis V,Del Vecchio C,Esposito F,Cheng YC,Tramontano E
Evidence	Besides, both compounds were tested also on RTs mutated in two amino acid residues within the RNase H domain, Q475A and A502F, part of conserved regions of RNase H domain, that have been shown to be involved in the binding of RNase H inhibitors into a pocket close to the RNase H catalytic site but acting as allosteric RNase H inhibitors.

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation