HIV Mutation Detail Information

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Mutation Information

Mutation Site	A4353G
Mutation Type	Nucleotide level
Gene/Protein/Region Type	Pol

Literature Information

PubMed PMID	25383358
Published Year	2014
Journal	Molecular therapy. Methods & clinical development
Title	Efficient Transduction of LEDGF/p75 Mutant Cells by Gain-of-Function HIV-1 Integrase Mutant Viruses.
Author	Wang H,Shun MC,Li X,Di Nunzio F,Hare S,Cherepanov P,Engelman A
Evidence	The sequencing of overlapping PCR products that covered the entire genomes with the exception of the env gene in both cases revealed a single nucleotide A to G change at position 4353 in pol, which corresponded to the substitution of Glu for Lys42 (K42E) in the NTD of IN.

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Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation