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Mutation Information
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Mutation Site
|
A394T |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
|
Gp120 |
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Combined Mutation
|
gp120.A394T+gp120.V295N |
Literature Information
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PubMed PMID
|
17509143
|
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Published Year
|
2007 |
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Journal
|
Retrovirology |
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Title
|
Immunogenicity of the outer domain of a HIV-1 clade C gp120. |
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Author
|
Chen H,Xu X,Jones IM |
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Evidence
|
Results and discussionCharacterisation of the 2G12 epitope reconstructed in clade C gp120Despite the sequence variation between HIV B and C clade gp120 reintroduction of two glycosylation triplets centred on the asparagine residues 295 and 392 (actual mutations V295N+A394T) was sufficient for MAb 2G12 recognition to the C clade HIV-1 envelope protein gp120CN54.
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HIV Mutation Detail Information