HIV Mutation Detail Information

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Mutation Information

Mutation Site	A360V
Mutation Type	Amino acid level
Gene/Protein/Region Type	RT
Combined Mutation	rt.N348I+rt.A360V;rt.E478Q+rt.N348I+rt.A360V

Literature Information

PubMed PMID	18547911
Published Year	2008
Journal	The Journal of biological chemistry
Title	Connection domain mutations N348I and A360V in HIV-1 reverse transcriptase enhance resistance to 3'-azido-3'-deoxythymidine through both RNase H-dependent and -independent mechanisms.
Author	Ehteshami M,Beilhartz GL,Scarth BJ,Tchesnokov EP,McCormick S,Wynhoven B,Harrigan PR,Götte M
Evidence	Accumulation of Transiently Formed DNA·RNA Hybrids—As a consequence of the diminished RNase H activity with A360V and N348I, medium sized fragments (e.g. fragments with RNase H cuts at positions -12, -9, and -8) accumulate when compared with WT RT that ultimately produces the -6 product (Fig. 2B).

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Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation