HIV Mutation Detail Information

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Mutation Information

Mutation Site	A329P
Mutation Type	Amino acid level
Gene/Protein/Region Type	Env
Genotype/Subtype	A
Immune Escape	Y

Literature Information

PubMed PMID	32295908
Published Year	2020
Journal	Journal of virology
Title	Development of a 3Mut-Apex-Stabilized Envelope Trimer That Expands HIV-1 Neutralization Breadth When Used To Boost Fusion Peptide-Directed Vaccine-Elicited Responses.
Author	Chuang GY,Lai YT,Boyington JC,Cheng C,Geng H,Narpala S,Rawi R,Schmidt SD,Tsybovsky Y,Verardi R,Xu K,Yang Y,Zhang B,Chambers M,Changela A,Corrigan AR,Kong R,Olia AS,Ou L,Sarfo EK,Wang S,Wu W,Doria-Rose NA,McDermott AB,Mascola JR,Kwong PD
Evidence	Here, we identify three mutations (3mut), Met302, Leu320, and Pro329, that stabilize the apex of the Env trimer in a prefusion-closed conformation and show antigenically, structurally, and immunogenically that combining 3mut with other approaches (e.g., repair and stabilize and glycine-helix breaking) yields well-behaved clade C-Env trimers capable of boosting the breadth of FP-directed responses.

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation