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Mutation Information
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Mutation Site
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A319T |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
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Gp120 |
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Country
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US |
Literature Information
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PubMed PMID
|
32156815
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Disease
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HIV infection/AIDS
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Published Year
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2020 |
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Journal
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mBio |
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Title
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Maternal Broadly Neutralizing Antibodies Can Select for Neutralization-Resistant, Infant-Transmitted/Founder HIV Variants. |
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Author
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Martinez DR,Tu JJ,Kumar A,Mangold JF,Mangan RJ,Goswami R,Giorgi EE,Chen J,Mengual M,Douglas AO,Heimsath H,Saunders KO,Nicely NI,Eudailey J,Hernandez G,Morgan-Asiedu PK,Wiehe K,Haynes BF,Moody MA,LaBranche C,Montefiori DC,Gao F,Permar SR |
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Evidence
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In contrast, linear V3 epitope-specific IgG MAb H650099 obtained from transmitting woman 9105 had strong binding activity to V3.C and V3.B, and its binding activity was ablated against C-terminal V3 mutant peptides V3.B F317A A319K D322A, V3.B F317L A319T D322R, and V3.B F317A, suggesting that amino acid residue F317 was required for the binding activity (Fig. S5C).
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HIV Mutation Detail Information