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Mutation Information
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Mutation Site
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A316W |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
|
Gp120 |
Literature Information
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PubMed PMID
|
29222332
|
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Published Year
|
2018 |
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Journal
|
The Journal of biological chemistry |
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Title
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Stabilization of the gp120 V3 loop through hydrophobic interactions reduces the immunodominant V3-directed non-neutralizing response to HIV-1 envelope trimers. |
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Author
|
de Taeye SW,de la Peña AT,Vecchione A,Scutigliani E,Sliepen K,Burger JA,van der Woude P,Schorcht A,Schermer EE,van Gils MJ,LaBranche CC,Montefiori DC,Wilson IA,Moore JP,Ward AB,Sanders RW |
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Evidence
|
The stabilization effect of the two substitutions described here and the previously described substitutions A316W and E64K, and the 73C–561C disulfide bond are additive.
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HIV Mutation Detail Information