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Mutation Information
|
Mutation Site
|
A2721G |
|
Mutation Type
|
Nucleotide level |
|
Gene/Protein/Region Type
|
P |
|
Viral Reference
|
LC500247.1
|
|
Country
|
China |
Literature Information
|
PubMed PMID
|
33947693
|
|
Clinical information
|
Yes
|
|
Disease
|
Liver cirrhosis;
Hepatocellular carcinoma
|
|
Published Year
|
2021 |
|
Journal
|
Clinical cancer research : an official journal of the American Association for Cancer Research |
|
Title
|
The Landscape of Cell-Free HBV Integrations and Mutations in Cirrhosis and Hepatocellular Carcinoma Patients. |
|
Author
|
Zheng B,Liu XL,Fan R,Bai J,Wen H,Du LT,Jiang GQ,Wang CY,Fan XT,Ye YN,Qian YS,Wang YC,Liu GJ,Deng GH,Shen F,Hu HP,Wang H,Zhang QZ,Ru LL,Zhang J,Gao YH,Xia J,Yan HD,Liang MF,Yu YL,Sun FM,Gao YJ,Sun J,Zhong CX,Wang Y,Kong F,Chen JM,Zheng D,Yang Y,Wang CX,Wu L,Hou JL,Liu JF,Wang HY,Chen L |
|
Evidence
|
As to genotype B, five HBV mutation hotspots were found significantly associated with HCC, among which A2721G, T2666C, A636T, and G167T (OR > 3) were identified as high-risk factors, whereas six mutation hotspots were inversely associated with HCC, as compared with patients with LC.
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HBV Mutation Detail Information