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Mutation Information
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Mutation Site
|
A233G |
|
Mutation Type
|
Nucleotide level |
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Gene/Protein/Region Type
|
E6 |
|
Genotype/Subtype
|
HPV18 |
Literature Information
|
PubMed PMID
|
30322153
|
|
Published Year
|
2018 |
|
Journal
|
International journal of molecular sciences |
|
Title
|
HPV-18 E6 Oncoprotein and Its Spliced Isoform E6*I Regulate the Wnt/β-Catenin Cell Signaling Pathway through the TCF-4 Transcriptional Factor. |
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Author
|
Muñoz-Bello JO,Olmedo-Nieva L,Castro-Muñoz LJ,Manzo-Merino J,Contreras-Paredes A,González-Espinosa C,López-Saavedra A,Lizano M |
|
Evidence
|
This effect is because 18E6SM harbors an A233G mutation in the donor splicing site that promotes a decrease in the expression of E6*I.
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HPV Mutation Detail Information