HIV Mutation Detail Information

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Mutation Information

Mutation Site	A20L
Mutation Type	Amino acid level
Gene/Protein/Region Type	Vpu
Combined Mutation	vpu.A24L+vpu.A20L
Genotype/Subtype	C

Literature Information

PubMed PMID	30717826
Published Year	2019
Journal	eLife
Title	HIV-1 Vpu is a potent transcriptional suppressor of NF-κB-elicited antiviral immune responses.
Author	Langer S,Hammer C,Hopfensperger K,Klein L,Hotter D,De Jesus PD,Herbert KM,Pache L,Smith N,van der Merwe JA,Chanda SK,Fellay J,Kirchhoff F,Sauter D
Evidence	In agreement with published data, mutations in an alanine interface in the transmembrane domain of Vpu (A15L/A19L in subtype B, A20L/A24L in subtype C) abrogated the ability of all three viruses to decrease tetherin surface levels (Figure 1D and Figure 1:figure supplement 2A) and to counteract tetherin-mediated restriction of virus release (Figure 1E and Figure 1:figure supplement 2B).

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation