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Mutation Information
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Mutation Site
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A19E |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
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Vpu |
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Country
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USA |
Literature Information
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PubMed PMID
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24465210
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Disease
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HIV infection/AIDS
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Published Year
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2014 |
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Journal
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PLoS pathogens |
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Title
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Preservation of tetherin and CD4 counter-activities in circulating Vpu alleles despite extensive sequence variation within HIV-1 infected individuals. |
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Author
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Pickering S,Hué S,Kim EY,Reddy S,Wolinsky SM,Neil SJ |
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Evidence
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Proteins defective for both CD4 downregulation and tetherin counteraction (i.e. less than the 81% cutoff for tetherin and 73.7% for CD4) contained a frame-shift (n = 1), an A19E change in the transmembrane domain (n = 1), mutations of the highly conserved regions just prior to (E29K;n = 2) and within (II43,46SL, R49G, R49T;n = 3) the first alpha-helix, and in the DSGNES hinge region between the two cytoplasmic alpha helices (D52V, SN53,55RH, S53N, E58K;n = 4), which contains two phosphorylated serines essential for interactions with the E3 ubiquitin ligase complex SCFbeta-TrCP, central to Vpu's function.
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HIV Mutation Detail Information