|
Mutation Information
|
Mutation Site
|
A18F |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
Vpu |
Literature Information
|
PubMed PMID
|
21237475
|
|
Published Year
|
2011 |
|
Journal
|
Virology |
|
Title
|
BST-2 is rapidly down-regulated from the cell surface by the HIV-1 protein Vpu: evidence for a post-ER mechanism of Vpu-action. |
|
Author
|
Skasko M,Tokarev A,Chen CC,Fischer WB,Pillai SK,Guatelli J |
|
Evidence
|
Vpu-I17A, -A18F, - W22L, and -S23L co-localized with BST-2 within endosomal membranes while effectively enhancing virion release and down-regulating surface BST-2.
|
|
|
HIV Mutation Detail Information