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Mutation Information
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Mutation Site
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A1846T |
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Mutation Type
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Nucleotide level |
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Gene/Protein/Region Type
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PreC |
Literature Information
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PubMed PMID
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26984835
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Disease
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Acute on chronic liver failure;
Chronic hepatitis B
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Published Year
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2016 |
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Journal
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Hepatology international |
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Title
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Association between hepatitis B virus basal core promoter/precore region mutations and the risk of hepatitis B-related acute-on-chronic liver failure in the Chinese population: an updated meta-analysis. |
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Author
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Nian X,Xu Z,Liu Y,Chen J,Li X,Xu D |
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Evidence
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RESULTS: Data for 13 studies with a total of 1,149 HB-ACLF and 1,867 chronic hepatitis B (CHB) cases were retrieved. Statistically significant summary ORs for HB-ACLF were obtained for T1753V (1.99; 95 % confidence interval 1.30-3.02) and A1762T/G1764A (2.11; 95 %, 1.75-2.54) in the BCP region and for A1846T (3.33; 95 %, 2.23-4.97), G1896A (2.78; 95 %, 2.07-3.74), and G1899A (3.09; 95 %, 1.82-5.25) in the PC region.
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HBV Mutation Detail Information