|
Mutation Information
|
Mutation Site
|
A1846T |
|
Mutation Type
|
Nucleotide level |
|
Gene/Protein/Region Type
|
PreC |
|
Relevant Drug
|
interferon(IFN) |
Literature Information
|
PubMed PMID
|
22061616
|
|
Disease
|
HBV-HCV coinfection
|
|
Published Year
|
2012 |
|
Journal
|
Antiviral research |
|
Title
|
Precore/core promoter mutations and hepatitis B virus genotype in hepatitis B and C dually infected patients treated with interferon-based therapy. |
|
Author
|
Hung CH,Chen CH,Lu SN,Wang JH,Hu TH,Huang CM,Tsai MC,Lee CM |
|
Evidence
|
Based on Cox proportional hazards model, young age (hazard ratio (HR)=0.952, P=0.001), sustained virological response to HCV (HR=4.638, P=0.044), C1766T mutation (HR=5.216, P=0.003) and A1846T mutation (HR=2.332, P=0.031) correlated with HBV DNA reactivation (>=2000IU/ml) after therapy.
|
|
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HBV Mutation Detail Information