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Mutation Information
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Mutation Site
|
A1846T |
|
Mutation Type
|
Nucleotide level |
|
Gene/Protein/Region Type
|
PreC |
|
Genotype/Subtype
|
C |
|
Country
|
China |
Literature Information
|
PubMed PMID
|
20959817
|
|
Disease
|
Chronic hepatitis B;
Liver cirrhosis;
Hepatocellular carcinoma
|
|
Published Year
|
2011 |
|
Journal
|
The American journal of gastroenterology |
|
Title
|
Association between the various mutations in viral core promoter region to different stages of hepatitis B, ranging of asymptomatic carrier state to hepatocellular carcinoma. |
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Author
|
Yin J,Xie J,Liu S,Zhang H,Han L,Lu W,Shen Q,Xu G,Dong H,Shen J,Zhang J,Han J,Wang L,Liu Y,Wang F,Zhao J,Zhang Q,Ni W,Wang H,Cao G |
|
Evidence
|
Multivariate regression analyses showed that age, male, abnormal alanine aminotransferase (ALT), T1768A, A1762T/G1764A, and A1846T were independently associated with cirrhosis compared with ASCs and the patients with CHB.
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HBV Mutation Detail Information