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Mutation Information
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Mutation Site
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A1762T |
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Mutation Type
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Nucleotide level |
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Gene/Protein/Region Type
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BCP |
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Country
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US |
Literature Information
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PubMed PMID
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32759756
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Published Year
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2020 |
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Journal
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Viruses |
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Title
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Advances with RNAi-Based Therapy for Hepatitis B Virus Infection. |
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Author
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van den Berg F,Limani SW,Mnyandu N,Maepa MB,Ely A,Arbuthnot P |
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Evidence
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Another example is the A1762T/G1764A sequence variation located in the basal core promoter (BCP), which is responsible for controlling pgRNA transcription and is associated with a higher viral load in patients infected with genotype C. In a study aimed at evaluating efficacy of expressed shRNAs against genotypes A-H, the researchers designed 21 shRNAs to target conserved regions.
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HBV Mutation Detail Information