|
Mutation Information
|
Mutation Site
|
A1762T |
|
Mutation Type
|
Nucleotide level |
|
Gene/Protein/Region Type
|
BCP |
|
Combined Mutation
|
bcp.G1764A+bcp.A1762T |
|
Genotype/Subtype
|
B;C |
|
Country
|
China |
Literature Information
|
PubMed PMID
|
32568442
|
|
Disease
|
Chronic hepatitis B;
Liver cirrhosis;
Hepatocellular carcinoma
|
|
Published Year
|
2020 |
|
Journal
|
Journal of viral hepatitis |
|
Title
|
The genetic polymorphism down-regulating HLA-DRB1 enhancer activity facilitates HBV persistence, evolution and hepatocarcinogenesis in the Chinese Han population. |
|
Author
|
Deng Y,Li P,Liu W,Pu R,Yang F,Song J,Yin J,Han X,Li C,Zhao J,Wang H,Cao G |
|
Evidence
|
Rs3135395-T, rs477515-T and rs2395178-G were inversely associated with the generation of A1762T/G1764A, T1753V and C1653T, the HCC-risk HBV mutations.
|
|
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HBV Mutation Detail Information