|
Mutation Information
|
Mutation Site
|
A1762T |
|
Mutation Type
|
Nucleotide level |
|
Gene/Protein/Region Type
|
BCP |
|
Combined Mutation
|
bcp.G1764A+bcp.A1762T |
|
Genotype/Subtype
|
C |
|
Viral Reference
|
AB981580
|
|
Relevant Drug
|
pegylated interferon(PEG-IFN) |
|
Country
|
Thailand |
Literature Information
|
PubMed PMID
|
31359359
|
|
Disease
|
Chronic hepatitis B
|
|
Published Year
|
2019 |
|
Journal
|
Virus genes |
|
Title
|
Next generation sequencing identifies baseline viral mutants associated with treatment response to pegylated interferon in HBeAg-positive chronic hepatitis B. |
|
Author
|
Chuaypen N,Payungporn S,Poovorawan K,Chotiyaputta W,Piratvisuth T,Tangkijvanich P |
|
Evidence
|
Based on NGS, the prevalence of T1753V (T1753C/A/G) and A1762T/G1764A variants were significantly lower in responders compared to non-responders (8.3% vs. 51.4%, P = 0.009 and 33.3% vs. 68.6%, P = 0.032, respectively).
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HBV Mutation Detail Information