|
Mutation Information
|
Mutation Site
|
A1762T |
|
Mutation Type
|
Nucleotide level |
|
Gene/Protein/Region Type
|
BCP |
|
Combined Mutation
|
bcp.G1764A+bcp.A1762T |
|
Genotype/Subtype
|
C;D |
|
Country
|
China |
Literature Information
|
PubMed PMID
|
30043328
|
|
Disease
|
HBV infection
|
|
Published Year
|
2018 |
|
Journal
|
Hepatology international |
|
Title
|
Clinical implication and viral mutation in basal core promoter/pre-core of hepatitis B virus C/D recombinant. |
|
Author
|
Li H,She Q,Liu Y,Ding Y,Shi S,Li J,Wu H,Wang Z |
|
Evidence
|
The distribution of C2 and C/D did not differ by disease status or liver function. Significantly higher levels of HBV DNA (6.7 +- 1.6 vs. 5.9 +- 1.5, p = 0.014), HBeAg (263.5 vs. 20.0, p = 0.013) and A1762T/G1764A double-mutations (81.0 vs. 61.8%, p = 0.018), but a lower frequency of G1896A stop mutation (33.6 vs. 76.5%, p < 0.001) was observed in patients with the C/D recombinant than in patients with genotype C2.
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HBV Mutation Detail Information